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Anti-NTH1 Rabbit Polyclonal Antibody

Dodávateľ: Thermo Scientific
The target sequence has 93% sequence homology with bovine proteins. Suggested positive control: Hela whole cell lysate, K562 cell extracts, Hela cell extracts, K562 whole cell lysate. Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.

Type: Primary
Antigen: NTH1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat, Mouse



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ŠPECIFIKÁCIE

Antigen symbol NTH1
Antigen name Endonuclease III like 1
Reactivity Rat, Human, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen synonyms OCTS 3, Endonuclease III like 1, NTHL 1
Gene ID 4913, 18207, 29541
Concentration 1.1 mg/ml
Immunogen A peptide derived from the human NTH1 conjugated to KLH.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.05% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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