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Anti-NUDT1 Rabbit Polyclonal Antibody

Dodávateľ: Thermo Scientific
The target sequence has 91% sequence homology with mouse and rat. Suggested positive control: Hela whole cell extract, antigen standard for NUDT1 (transient overexpression lysate). Oxygen radicals damage chromosomal DNA causing cell death and inducing mutations. Among the various classes of DNA damage caused by oxygen radicals, an oxidized form of guanine base (8-oxoguanine) appears to be important as it can pair with cytosine and adenine and G:C to T:A transversion mutation occurs. A significant amount of 8-OxoG is formed in the chromosomal DNA of mammalian cells, with most damaged nucleotides excised from the DNA and excreted in the urine. Along with 8-oxoG being present in oxidatively damaged DNA, 8-oxo-deoxyguanosine (8-oxo-dGTP) is formed in the nucleotide pool during normal cellular metabolism and following oxidative stress. The 8-oxo-dGTP nucleotide can be incorporated in DNA during polymerization and can result in a mispairing unless repaired. MTH converts 8-oxo-dGTP in the nucleotide pool to the monophosphate and prevents the misincorporation of 8-oxo-dGTP into DNA (Figure courtesy of Dr. Mark Kelley). MTH also recognizes 8-oxo-rGTP, which could incorporate into RNA during gene transcription leading to missense or nonsense protein production.

Type: Primary
Antigen: NUDT1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat, Human



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Antigen symbol NUDT1
Antigen name 7,8-dihydro-8-oxoguanine triphosphatase
Reactivity Human, Rat, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen synonyms NUDIX Motif 1, NUDT1, Nucleoside Diphosphate Linked Moiety X Motif 1
Gene ID 4521, 17766, 117260
Concentration 1 mg/ml
Immunogen A c-terminal peptide derived from the human MTH1 conjugated to KLH.
Purification Antigen affinity chromatography
Form Liquid
Storage buffer PBS, 0.02% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping temperature Ice
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