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Anti-PHD3 Rabbit Polyclonal Antibody

Dodávateľ: Thermo Scientific
Suggested positive control: antigen standard for EGLN3 (transient overexpression lysate). HIF prolyl hydroxylase 3 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-1, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(564) and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may also play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissues, promoting cell death through a caspase-dependent mechanism.

Type: Primary
Antigen: PHD3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Rat, Mouse



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100 µL 100 µl PIEAPA116526 Blocked
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ŠPECIFIKÁCIE

Antigen symbol PHD3
Antigen name HIF Prolyl Hydroxylase 3
Reactivity Rat, Human, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms HIFPH3, EGL9 homolog of C. elegans 3, Prolyl Hydroxylase Doma, Factor responsive smooth muscle protein, P4H3, EGLN3, HIFP4H3, HIF Prolyl Hydroxylase 3
Gene ID 112399, 54702, 112407
Concentration 1 mg/ml
Immunogen Synthetic peptide containing residues between 50-100 of human PHD3/HIF Prolyl Hydroxylase 3 using the numbering given in entry NP_0713561 (GeneID 112399)
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.5% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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