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Anti-FXR Rabbit Polyclonal Antibody

Dodávateľ: Thermo Scientific
Suggested positive control: HeLa nuclear extract. The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed orphan receptors because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.

Type: Primary
Antigen: FXR
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human

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Antigen symbol FXR
Antigen name Nuclear Receptor Subfamily 1 Group H Member 4
Reactivity Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western blot Yes
ImmunoFluorescence Yes
Antigen synonyms RXR-interacting protein 14, Farnesoid X-activated receptor, Bile acid receptor, Retinoid X receptor-interacting protein 14, Farnesol receptor HRR-1
Gene ID 9971
Concentration 5.7 mg/ml
Immunogen Synthetic peptide made to the C-terminus of human FXR.
Purification Antigen affinity chromatography
Form Liquid
Storage buffer tris glycine, 0.15M NaCl, 0.05% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping temperature Ice
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