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Anti-Beclin 1 Rabbit Polyclonal Antibody

Dodávateľ: Thermo Scientific
The target sequence has 88% sequence homology with rat. Suggested positive control: antigen standard for BECN1 (transient overexpression lysate). Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biologic processes in which autophagy is important such as cell differentiation and nutritional stress responses.

Type: Primary
Antigen: Beclin 1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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100 µL 100 µl PIEAPA116857 Blocked
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ŠPECIFIKÁCIE

Antigen symbol Beclin 1
Antigen name Beclin 1
Reactivity Mouse, Human, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Antigen synonyms CTIP-1 COUP-TF interacting protein 1
Gene ID 8678, 56208, 114558
Concentration 1 mg/ml
Immunogen Synthetic peptide to human Beclin 1, containing residues within 1-100.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.02% sodium azide, pH 7.4
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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