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Anti-PUMA Rabbit Polyclonal Antibody

Dodávateľ: Thermo Scientific
In Western blot, a band at ~16 kDa is seen, representing the beta form of PUMA. Reactivity against the alpha form of PUMA is unknown. Suggested positive control: HL-60 whole cell lysate, antigen standard for BBC3 (transient overexpression lysate). A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.

Type: Primary
Antigen: PUMA
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human



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100 µL 100 µl PIEAPA116861 Blocked
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ŠPECIFIKÁCIE

Antigen symbol PUMA
Antigen name p53 Upregulated Modulator of Apoptosis
Reactivity Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoFluorescence Yes
Antigen synonyms Bcl-2 binding component 3, JFY-1, p53 Upregulated Modulator of Apoptosis
Gene ID 27113
Concentration 5.65 mg/ml
Immunogen A synthetic peptide made to a region within the C-terminus of the human PUMA protein sequence (between residues 150-193).
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 0.15M NaCl, 0.05% sodium azide
Storage temperature Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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