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Anti-IRE1A Rabbit Polyclonal Antibody

Dodávateľ: Thermo Fisher Scientific
PIEAPA116928EA 0 EUR
PIEAPA116928
Anti-IRE1A Rabbit Polyclonal Antibody
Protilátky
This antibody does not detect monkey IRE1 alpha. Suggested positive control: Pancreatic islets and insulinoma cells. IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. It is a transmembrane protein that has both serine-threonine kinase and endoribonuclease activities. Null mutants are viable, but IRE1 is essential for viablility under stress conditions that cause unfolded proteins to accumulate in the ER.

Type: Primary
Antigen: IRE1A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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