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Anti-LOX Rabbit Polyclonal Antibody

Dodávateľ: Thermo Scientific
PA1-16953 is specific for the ~58 kDa LOX protein. This is a highly glycosylated protein and therefore, other bands may be seen at ~32 kDa (non-glycosylated form) 50 kDa and 58 kDa (glycosylated forms). Suggested positive control: human and mouse kidney lysate, antigen standard for LOX (transient overexpression lysate), human kidney protein, mouse kidney protein. Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.

Type: Primary
Antigen: LOX
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Human



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100 µL 100 µl PIEAPA116953 Blocked
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ŠPECIFIKÁCIE

Antigen symbol LOX
Antigen name Lysyl oxidase
Reactivity Human, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen synonyms Protein-lysine 6-oxidase antibody, Lysyl oxidase antibody., EC 1.4.3.13 antibody
Gene ID 16948, 4015
Concentration 1.3 mg/ml
Immunogen Synthetic peptide between amino acids 200-300 of the human LOX protein.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 0.15M NaCl, 0.05% sodium azide
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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