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Anti-CLIP1 Goat Polyclonal Antibody

Dodávateľ: Thermo Scientific
This antibody is predicted to react with canine, mouse, porcine and rat based on sequence homology. CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.

Immunohistochemistry: 2-4µg/ml, Western Blot: 1-3 ug/ml

Type: Primary
Antigen: CLIP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Goat
Isotype: IgG
Reactivity: Human



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OBJEDNAŤ

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Veľkosť Pk Číslo v katalógu VWR Množstvo
100 ug 100 µG PIEAPA519167 Blocked
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ŠPECIFIKÁCIE

Antigen symbol CLIP1
Antigen name CAP-GLY Domain containing linker Protein 1
Reactivity Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody type Primary
Host Goat
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
Antigen synonyms MGC131604, RSN, restin (Reed-Steinberg cell-expressed intermediate filament-associated protein), CAP-GLY domain containing linker protein 1, cytoplasmic linker 1, CYLN1, Reed-Steinberg cell-expressed intermediate filament-associated protein, restin, CLIP1, CLIP, CLIP170, CLIP-170
Gene ID 6249
Concentration 0.5 mg/ml
Immunogen Synthetic peptide sequence (PHSTHHGSRGEERP) corresponding to the C-terminus amino acids of CLIP1
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer TBS, 0.5% BSA, 0.02% sodium azide, pH 7.3
Storage temperature -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
Brand Name Invitrogen
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