Anti-NKX2-1 Mouse Monoclonal Antibody (CF543) [clone: 8G7G3/1 NX2.1/690]

Dodávateľ: Biotium
BNC430907-100EA 216.51 EUR
BNC430907-100 BNC430907-500
Anti-NKX2-1 Mouse Monoclonal Antibody (CF543) [clone: 8G7G3/1 NX2.1/690]
Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Type: Primary
Antigen: NKX2-1
Clonality: Monoclonal
Clone: 8G7G3/1 NX2.1/690
Conjugation: CF543
Host: Mouse
Isotype: IgG
Reactivity: Human, Mouse, Rat
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