Anti-MUC1 Mouse Monoclonal Antibody (CF680R) [clone: MUC1/955]

Dodávateľ: Biotium
BNC810955-500EA 596.11 EUR
BNC810955-500 BNC810955-100
Anti-MUC1 Mouse Monoclonal Antibody (CF680R) [clone: MUC1/955]
This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

Type: Primary
Antigen: MUC1
Clonality: Monoclonal
Clone: MUC1/955
Conjugation: CF680R
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Mouse
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