Anti-FBXO5 Mouse Monoclonal Antibody (CF405M) [clone: EMI1/1176]

Dodávateľ: Biotium
BNC051176-100EA 216.51 EUR
BNC051176-100 BNC051176-500
Anti-FBXO5 Mouse Monoclonal Antibody (CF405M) [clone: EMI1/1176]
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.

Type: Primary
Antigen: FBXO5
Clonality: Monoclonal
Clone: EMI1/1176
Conjugation: CF405M
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human
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